Gusobanukirwa no gukoresha Gorelatide

Intangiriro

Gorelatide, izwi kandi nka n-acetyl-serine - acide aspartic - proline - proline - (N-Acetyl-Ser-Asp-Lys-Pro), mu magambo ahinnye yitwa Ac-SDKP, ni tetrapeptide ya endogenous, azote ya azote, ikwirakwizwa cyane muri imyenda itandukanye hamwe namazi yumubiri mumubiri.Iyi tetrapeptide irekurwa na prolyl oligopeptidase (POP), iterwa ahanini na thimosine yabanjirije.Ubwinshi bwamaraso mubisanzwe mubipimo bya nanomole.

okinetics

Nk’uko ubushakashatsi bwakozwe na farumasi bwa Gorelatide bubitangaza, nyuma yo gutera inshinge, Gorelatide yangirika vuba hamwe nubuzima bwa kimwe cya 4 ~ 5min gusa.Gorelatide ikurwa muri plasma yabantu nuburyo bubiri:①Angiotensin-ihindura enzyme (ACE) -iyobora hydrolysis;②Akayunguruzo.Hydrolysis ya angiotensin ihindura enzyme (ACE) ninzira nyamukuru ya metabolism ya gorelatide.

Igikorwa cyibinyabuzima

Gorelatide ni ubwoko bwimikorere myinshi ya physiologique igenga ibikorwa bitandukanye byibinyabuzima.Byari byavuzwe mbere ko Gorelatide ishobora kubuza kwinjira mu ngirabuzimafatizo y’umwimerere ya hematopoietic mu cyiciro cya S kandi bigatuma ihagarara mu cyiciro cya G0, ikabuza ibikorwa by’uturemangingo twa hematopoietic.Nyuma byaje kugaragara ko Gorelatide ishobora kongera ubushobozi bwo kongera icyorezo cya epidermal iteza imbere imiyoboro y'amaraso no kwihutisha gukira ibikomere byangiritse byanduye.Gorelatide irashobora kubuza gutandukanya ingirangingo z'amagufwa ya magufa yatewe na MGM muri macrophage, bityo ikagira uruhare rwo kurwanya inflammatory.Gorelatide iherutse kuboneka kugirango ibuze ikwirakwizwa rya selile zitandukanye.

Koresha

Nkibinyabuzima bya polypeptide, Gorelatide irashobora gukoreshwa nkibikoresho fatizo byibiyobyabwenge.