Uru rupapuro rusobanura muri make ticcotide n'ingaruka zayo muri farumasi

Tecosactideni synthique 24-peptide corticotropin analogue.Urutonde rwa aside amine irasa na 24 amine acide ya amino-terminal ya corticotropine karemano (abantu, bovine na porcine), kandi ifite ibikorwa byumubiri nkibya ACTH bisanzwe.Ati: “Irangwa no kutagira antibody, muri rusange nta ngaruka mbi zikomeye, kandi ikwiriye cyane cyane ku barwayi bafite allergie cyangwa badafite ingaruka nziza kuri corticotropine.”

Ati: “Itera hyperplasia ya adrenal, itera ururenda rwa hormone adrenocortique, cyane cyane (cortisol) na mineralocorticoide nka corticosterone, kandi ikanatera ururenda rwa andorogene, ariko bikagira ingaruka nke.”

Uru rupapuro rusobanura muri make ticcotide n'ingaruka zayo muri farumasi

Nta ngaruka nke zagize kuri aldosterone.Igice cya kabiri cyubuzima ni amasaha 3.Muri 2008, FDA yemeje Tecokotide yo muri Novartis kugirango isuzume ibura rya adrenal.Kuri ubu irimo kwigwa muri RandboudUniversity kugirango ivure idasanzwe idasanzwe ya nepropatique.

Uburyo bwose bwamazi ya synthesis uburyo bwo guhuza uburyo bwa ticacotide.Ubu buryo bufite intambwe nyinshi, igihe kirekire cyo gusanisha, kandi gisaba catalizator ihenze hamwe nibikoresho byumuvuduko mwinshi, bifite ibibi byigiciro kinini, umwanda mwinshi, ibyago byo gukora, numusaruro muke.Byatangajwe ko synthesis umwe umwe ukoresheje ingamba zo kurinda Z, aho hydrogenation ikoreshwa mugukuraho ibirindiro kuri buri ntambwe, ifite intambwe ndende, imikorere itoroshye, igiciro kinini n'umusaruro muke.Serine ikunda kuvangura amoko kubera guhuza umwe-umwe mugihe cyo kwezwa, bigoye kweza.

“Kimwe na hormone ya adrenocorticotropique, ticcotide itera imisemburo ya cortique (cyane cyane cortisol) iva muri cortex.”Kubwibyo, nta ngaruka zagize ku barwayi bafite imikorere mibi ya adrenocortical.

Ticocotide ni polypeptide ya sintetike igizwe na aside amine 24.Irasa muburyo bwa mbere kugeza kuri 24 ya aminide acide ya ACTH.Ubuyobozi bwimitsi bwongera umuvuduko wamaraso cortisol.Igitonyanga gikomeza gutembera kigomba gukoreshwa kugirango amaraso ya cortisol agabanuke.Kubitera inshinge, serumu cortisol yageze hejuru ya 1h nyuma yo guterwa.Nyuma yibyo, cortisol ihanitse irashobora kubungabungwa amasaha agera kuri 24.