L.Dipeptide igizwe na β-alanine na L-histidine.Carnosine ifite antioxydants itandukanye ya selile, kurwanya-gusaza hamwe nubuvuzi bwubuzima bwa physiologique hamwe ningaruka zubuvuzi, nka hypertension, indwara z'umutima, cataracte ya senile, gukira ibisebe, kurwanya ibibyimba, kwipimisha icyitegererezo, kurwanya anti-stress nibindi.
Uruhare rwa
Carnosine ni karnosine yabonetse n'umuhanga mu Burusiya Gulevich hamwe na karnitine.Mu Bwongereza, Koreya, Uburusiya, n'Ubushinwa, ubushakashatsi bwerekanye ko karnosine ifite imbaraga za antioxydants kandi ifitiye abantu akamaro.Carnosine yerekanwe gukuraho ubwoko bwa ogisijeni (ROS) iterwa no okiside ikabije ya aside irike muri selile mugihe cya stress ya okiside, hamwe na α-β aldehydes idahagije.
Ubushakashatsi bwinshi bwerekanye ko N-acetylcarnosine igira ingaruka nziza mukurinda no kuvura cataracte.Bumwe muri ubwo bushakashatsi bwerekanye ko karnosine yahinduye cataracte yatewe na kristaline itagaragara mu mbeba zatewe no guhura na guanidine.Nubwo ibi birego bishyigikira inyungu nyinshi zijyanye nijisho nko kuvura karnotine kuvura cataracte, kugeza ubu, ntabwo zishyigikiwe byimazeyo n’ubuvuzi rusange.Urugero, Royal Orthopedics ya Royal, yari yavuze ko karnosine itari ifite umutekano cyangwa ngo igire akamaro mu kuvura indwara ya cataracte.
Raporo yo mu 2002 ivuga ko karnosine ishobora guteza imbere imibanire myiza no kongera amagambo akoreshwa n’abana bafite ubumuga bwo mu mutwe, ariko iterambere ryavuzwe mu bushakashatsi rishobora no guturuka ku kunoza, gushyiramo umwanya, cyangwa ibindi bintu bitanditswe muri ubu bushakashatsi.
Uburyo bwa synthesis
Kugeza ubu, uburyo bwo gukora karnosine bufite aho bugarukira: bitewe no kugabanuka kwuruhande, iyi myitwarire ikorwa hifashishijwe impeta ya L-histidine imidazole.L-histidine izunguruka byibuze 0.8% mugikorwa cya reaction, kugabanya umusaruro wibicuruzwa;Muri icyo gihe, biragoye gutandukanya L-karnosine hamwe nubuziranenge bwiza bwa optique hamwe nuruvange rwangiza (uburyo bwayo bwo kuzunguruka, isomers imidazole, nibindi), bigira ingaruka kubucuruzi bwubucuruzi, kuko ibyo bivanga bifite imiterere-karemano ya L-karnosine.Bitewe nuko habaho imvange, L-karnosine yavuyemo ni uburozi, aho kuba umwimerere wambere.
Uburyo bushya bwo gukora L-karnosine nuburyo bukurikira: anhydride ya phthalic reaction β-alanine hamwe na anhydride ya phthalic β-phthaloylalanine, chlorine reagent chloride phthaloyl-β-phthaloylalanine kuri phthaloyl-alanine β-alanyl chloride;L-trialkylsilane ikingira ikingira reaction hamwe na trialkylchlorosilane cyangwa hexahydroxysilane, ikora hamwe na phthalyl β-alanyl chloride ya hydrochloride, ikuraho itsinda ririnda inzoga ya anhydrous, kandi ikomatanya hydrochloride mumuti wa alkaline hamwe na hydrocide hydratzide hydrolyz. L-karnosine muri alcool idasanzwe.Iki gicuruzwa nimpeta ya imidazole kuri L-irinzwe na histidine kugirango wirinde ingaruka zimpeta ya imidazole kuri L-histidine nibindi bintu, hanyuma ubone L-karnosine nziza ifite ingaruka nke hamwe numusaruro mwinshi nibirimo.
Igihe cyo kohereza: Ukwakira-24-2023