Inganda zubwiza zakoze ibishoboka byose kugirango zuzuze icyifuzo cyabagore cyo gusaza.Mu myaka yashize, peptide ishyushye yakoreshejwe cyane mu nganda zo kwisiga.Kugeza ubu, amoko agera kuri 50 y’ibikoresho fatizo yatangijwe n’abakora amavuta yo kwisiga mu mahanga.Bitewe nuburemere bwibitera gusaza, ubwoko butandukanye bwubwiza peptide bugira uruhare rwihariye muburyo butandukanye kugirango ugere ku ntego yo kurwanya inkari.Uyu munsi, reka turebe peptide zitandukanye nimibare kurutonde rwibigize.
Ibyiciro gakondo byagabanije peptide yuburanga hakoreshejwe uburyo bwa peptide ya signal, Neurotransmitter ibuza peptide, na peptide yitwa Carried peptide.
Imwe.Ikimenyetso cya peptide
Ibimenyetso bya peptide biteza imbere poroteyine ya matrix, cyane cyane kolagen, kandi irashobora kandi kongera umusaruro wa elastine, aside hyaluronike, glycosaminoglycans, na fibronectine.Iyi peptide iteza imbere synthesis ya kolagen yongera ibikorwa bya selile, bigatuma uruhu rusa neza kandi rukiri muto.Bisa nibintu gakondo birwanya imyunyu ngugu, nka vitamine C, ibikomoka kuri vitamine A.Ubushakashatsi bwakozwe na P&G bwerekanye ko palmitoyl pentapeptide-3 iteza imbere umusaruro wa poroteyine zo mu bwoko bwa kolagen hamwe n’izindi ndangagitsina zidasanzwe, harimo elastine na fibronectine.Palmitoyl oligopeptides (palmitoyl tripeptide-1) ikora ibintu bimwe, niyo mpamvu palmitoyl oligopeptide ikoreshwa cyane.Palmitoyl pentapeptide-3, palmitoyl tripeptide-1, palmitoyl hexapeptide, palmitoyl tripeptide-5, hexapeptide-9 na nutmeg pentapeptide-11, bikunze kugurishwa ku isoko, ni peptide yerekana ibimenyetso.
Babiri.Neurotransmitter peptide
Iyi peptide nuburyo bwa botoxine.Irabuza SNARE reseptor synthesis, ibuza kurekura cyane acetycholine yuruhu, ikabuza amakuru kwanduza imitsi kwanduza imitsi, kandi ikoroshya imitsi yo mumaso kugirango ituze imirongo myiza.Iyi peptide ikoreshwa cyane nka peptide yerekana ibimenyetso kandi irakwiriye cyane cyane gukoreshwa ahantu imitsi igaragarira cyane (imfuruka y'amaso, mu maso, no mu gahanga).Ibicuruzwa byerekana peptide ni: acetyl hexapeptide-3, acetyl octapeptide-1, pentapeptide-3, dipeptide ophiotoxin na pentapeptide-3, muri byo hakoreshwa cyane ni acetyl hexapeptide-3.
Bitatu.Yitwa peptide
Tripeptide (Gly-L-His-L-Lys (GHK)) muri plasma yabantu ifitanye isano ikomeye na ion z'umuringa, zishobora guhita zikora peptide ikomeye y'umuringa (GHK-Cu).Gukuramo umuringa nikintu cyingenzi mugukiza ibikomere hamwe nuburyo bwinshi bwo gukora ibintu.Ubushakashatsi bwerekanye ko GHK-Cu ishobora guteza imbere gukura, kugabana no gutandukanya ingirabuzimafatizo n’imitsi ifitanye isano n’umubiri, kandi bishobora guteza imbere gukira ibikomere no gukura kwa mikorobe.Ibicuruzwa bigereranywa na peptide y'umuringa ni peptide y'umuringa.
Bane.ubundi bwoko bwa peptide
Igikorwa rusange cya peptide gakondo ni ukurwanya inkari no kurwanya gusaza usibye peptide y'umuringa (peptide y'umuringa ifite ibintu byinshi icyarimwe).Mu myaka yashize, peptide zitandukanye zagiye ziyongera, zimwe muri zo zigera ku ntego yo kurwanya inkari no kurwanya gusaza biturutse ku buryo bushya kandi bushingiye ku bitekerezo (anti-free radical okiside, anti-carbonylation, anti-inflammatory, anti -edema no guteza imbere gusana dermal).
1. Kurwanya uruhu, guteza imbere uruhu
Palmitoyl dipeptide-5, hexapeptide-8, cyangwa hexapeptide-10 ikomera uruhu mukangura LamininV yo mu bwoko bwa IV na VII kolagen, naho palmitoyl tetrapeptide-7 igabanya umusaruro wa interleukin-6 kandi igabanya umuriro.Ubu bwoko bwa peptide ikora niterambere cyane, moderi nshya zihora ziyongera, ikoreshwa cyane ni palm tetrapeptide-7.
Glycosylation
Iyi peptide irashobora kurinda kolagen kurimbuka no guhuzwa nubwoko bwa karubone (RCS), mugihe peptide zimwe na zimwe zirwanya karubone zishobora kwikuramo radicals yubusa.Kwita ku ruhu gakondo biha agaciro kanini anti-radicals, bigenda bigaragara ko birwanya karubone.Carnosine, tripeptide-1 na dipeptide-4 ni peptide ifite imirimo nkiyi
3. Kunoza uburibwe bw'amaso, kunoza microcirculation no gushimangira amaraso
Acetyltetrapeptide-5 na dipeptide-2 ninzitizi zikomeye za ACE zitera umuvuduko wamaraso kubuza ihinduka rya angiotensin I na angiotensin II.
4. Guteza imbere gusana dermal
Palmitoyl hexapeptidde-6, inyandikorugero ya peptide yerekana ubudahangarwa bw'umubiri, irashobora gukangura neza ikwirakwizwa rya fibroblast no guhuza, synthesis ya kolagen hamwe no kwimuka kwakagari.
Kurwanya peptide yavuzwe haruguru yashyizwemo byinshi.Usibye peptide yo kurwanya gusaza twavuze haruguru, izindi peptide nyinshi zo kwisiga zatejwe imbere mu nganda, nko kwera, kongera amabere, kugabanya ibiro n'ibindi.
Igihe cyo kohereza: Werurwe-22-2023