Ni uruhe ruhare rwa fosifora muri peptide?

Fosifora igira ingaruka mubice byose byubuzima bwimikorere ya selile, kandi protein kinase igira ingaruka kumpande zose zimikorere yitumanaho rudasanzwe muguhuza inzira zerekana inzira na selile.Nyamara, fosifora aberrant nayo niyo itera indwara nyinshi;byumwihariko, protein kinase ihindagurika hamwe na fosifata irashobora gutera indwara nyinshi, kandi uburozi karemano bwinshi hamwe na virusi nabyo bigira ingaruka muguhindura fosifora ya proteine ​​zo mu nda.

Fosifora ya serine (Ser), threonine (Thr), na tyrosine (Tyr) ni uburyo bwo guhindura poroteyine ihinduka.Bagira uruhare mugutunganya ibikorwa byinshi bya selile, nkibimenyetso bya reseptor, ishyirahamwe rya poroteyine no gutandukanya, gukora cyangwa kubuza imikorere ya poroteyine, ndetse no kubaho kwakagari.Fosifate yishyuzwa nabi (amafaranga abiri atemewe kumatsinda ya fosifate).Kubwibyo, kwiyongera kwabo guhindura imiterere ya poroteyine, ubusanzwe ni ihinduka rihuza, biganisha ku ihinduka ryimiterere ya poroteyine.Iyo itsinda rya fosifate rivanyweho, ihinduka rya poroteyine rizasubira uko ryahoze.Niba poroteyine ebyiri zihuza zigaragaza ibikorwa bitandukanye, fosifora irashobora gukora nka molekile ihindura poroteyine kugirango igenzure ibikorwa byayo.

Imisemburo myinshi igenga imikorere yimisemburo yihariye yongera fosifora yibisigisigi bya serine (Ser) cyangwa threonine (Thr), kandi fosifora ya tirozine (Tyr) irashobora guterwa nimpamvu zikura (nka insuline).Amatsinda ya fosifate yaya acide amine arashobora gukurwaho vuba.Rero, Ser, Thr, na Tyr imikorere nka molekuline ihindura mugutunganya ibikorwa bya selile nko gukwirakwiza ibibyimba.

Peptide ya sintetike igira uruhare runini mukwiga protein kinase substrates n'imikoranire.Nubwo bimeze bityo ariko, hari ibintu bimwe na bimwe bibangamira cyangwa bigabanya imikoreshereze y’ikoranabuhanga rya fosiforeptide, nko kutabasha kugera kuri automatisation yuzuye ya synthèse-fonctionnement no kutagira aho bihurira hamwe na platform isanzwe yisesengura.

Ihuriro rishingiye kuri peptide synthesis hamwe na tekinoroji yo guhindura fosifora iratsinda izo mbogamizi mugihe tunoza imikorere ya synthesis hamwe nubunini, kandi urubuga rukwiranye no kwiga protein kinase substrate, antigene, molekile zihuza, hamwe na inhibitor.