Peptide urunigi rwakoreshejwe cyane mubice byinshi, cyane cyane mugutezimbere ibiyobyabwenge, ubushakashatsi bwibinyabuzima na biotechnologiya.Peptide yuburebure nuburyo bukurikiranye irashobora guhuzwa binyuze muri peptide yumunyururu wa peptide mugutegura ibiyobyabwenge, abatwara ibiyobyabwenge, isesengura rya poroteyine, ubushakashatsi bukora nibindi.None se icyerekezo cya peptide ya sintetike niyihe?Uyu munsi, Gutuo Xiaobian azaguha igisubizo kirambuye hepfo.
Niki cyerekezo cya peptide yihariye?Waba uzi izi ngingo?
Peptide yumunyururu irashobora kugerwaho hiyongereyeho intambwe ya molekile ya aside amine kumurongo wa peptide ihari, ikabyara peptide nshya.Bitewe no gukura kuva kuri N kugera kuri C peptide, icyerekezo rero cya synthesis nacyo kiva kuri N kugeza kuri C. Ibi biterwa nuko C terminal na N terminal amino acide hagati ya peptide yububiko, aminide acide ya carboxyl (C) hamwe na amino iriho (N) kurangiza urunigi rwa peptide, bitera umurunga mushya wa peptide.Noneho, icyerekezo cya synthesis kuva N iherezo kugeza C.
Peptide synthesis ihuza cyane molekile ya aside amine ikoresheje uburyo bwa chimique kugirango ikore inzira ya peptide.Kugirango bisobanuke neza, synthesis ya polypeptide ihuza molekile ya aside amine, nayo, ishobora gukorwa nububiko bwimiti kugirango yubake inzira ya peptide.Peptide yumunyururu urashobora gukorwa mubisanzwe hamwe na synthesis ya fase ikomeye.Muri synthesis ya fonctionnement, aside amine yambere ihujwe nibintu bikomeye, hanyuma urunigi rwa peptide rwongerwa mukurikirane hiyongereyeho intambwe ya aside amine.
Hejuru ni ntoya igizwe no kumenyekanisha ibyiciro bya peptide ninshingano zubumenyi bujyanye nayo, tinto yibanze kuri synthesis ya peptide, imvugo ya protein, gutegura antibody, nibindi, ikora inganda za peptide mumyaka myinshi, ubwiza bwibicuruzwa byo mucyiciro cya mbere , ikaze imbaga yabakiriya baza kugisha inama.
Igihe cyo kohereza: Ukuboza-08-2023