Conotoxin ni iki?Urashobora gukuraho iminkanyari?

conotoxine (conopeptide, cyangwa CTX), cocktail ya peptide nyinshi ya monotoxique isohoka mu miyoboro yuburozi na glande ya Marine gastropod idafite ubuzima (Conus).Ibice byingenzi ni imiti ikora polypeptide ikora cyane cyane kumiyoboro ya calcium itandukanye hamwe na reseptor ya sisitemu.Uburozi bwa buri cone burimo peptide ikora 50 kugeza 200.Ubwoko butandukanye bwibisimba birimo peptide ikora, kabone niyo udusimba tumwe twa conic bitewe n'uturere dutandukanye, ibice byuburozi birashobora kuba bitandukanye, mubyukuri hashobora kubaho peptide zirenga ibihumbi 50 zikora muburozi bwa conic.Conotoxine igizwe ahanini n’ibisigisigi 10 ~ 40, birimo amatsinda abiri cyangwa atatu y’umubano wa disulfide, ugasanga ari aside ntoya ya nucleic aside ntoya ya peptide ya biologiya neurotoxic peptide, nubundi bunini bwinshi bwa disulfide ya peptide ntoya, irashobora gukoreshwa muburyo bwose; y'imiyoboro ya calcium n'ubwoko bwa reseptor n'ubwoko butandukanye.

Ingaruka za conotoxine ku ruhu rwuruhu ni izi zikurikira:

Conotoxin, ni umuryango wa conotoxine, ni ubwoko bwinyongera bwo kurwanya gusaza kuruhande, ibi ni ukubera ko bishobora kugabanya ubuso bwuruhu rwumurongo mwiza, bikagabanya uruhu rukomeye, bigahinduka urumuri kandi byoroshye, bigashira imirongo myiza, hanyuma bikabona ibya buri wese ukunda.Yitwa “Anti-gusaza inyenyeri.”

Conotoxine irashobora kubuza umusaruro wumurongo mwiza wo mumaso, kunoza kuruhuka kwuruhu, kunoza uruhu rworoshye, kunoza ubwiza bwuruhu hamwe nuburebure bwumurongo.Ifasha kugabanya kubyimba kwuruhu, kwemerera uruhu gusana ubuhanga bwarwo no kuzamura ubwiza bwuruhu.

Conotoxin yabaye imwe mu mikorere ikoreshwa cyane yo kurwanya gusaza kubera imikorere yayo myiza mu kurwanya gusaza.Hamwe nubuhanga budasanzwe, conotoxine irashobora gushirwa muruhu rwo mumaso kugirango irusheho gukomera.

Conotoxine nk'ubwoko bwo kurwanya gusaza, ifite ingaruka zikomeye zo kurwanya gusaza, bityo irashobora kugirira akamaro kanini kunoza imiterere y'uruhu, kuvanaho iminkanyari, gutuma uruhu rusa nkurubyiruko rwiza cyane rworoshye.