Peptide yinjira mu ngirabuzimafatizo ni iki?

Peptide yinjira mu ngirabuzimafatizo ni peptide ntoya ishobora kwinjira byoroshye muri selile.Iki cyiciro cya molekile, cyane cyane CPP zifite ibikorwa bigamije, gifite amasezerano yo kugeza ibiyobyabwenge neza muri selile.

Kubwibyo, ubushakashatsi kuri bwo bufite ubusobanuro bwibinyabuzima.Muri ubu bushakashatsi, CPP ifite ibikorwa bitandukanye bya transembrane yizwe kurwego rwikurikiranya, igerageza kumenya ibintu bigira ingaruka kumikorere ya transembrane ya CPP, itandukaniro ryikurikiranya hagati ya CPP nibikorwa bitandukanye na NonCPPs, inashyiraho uburyo bwo gusesengura ibinyabuzima bikurikirana.

Urutonde rwa CPP na NonCPPs rwabonetse mububiko bwa CPPsite hamwe nubuvanganzo butandukanye, hamwe na peptide ya transembrane (HCPPs, MCPPs, LCPPs) hamwe nibikorwa byo hejuru, biciriritse, na bike byakuwe mubikorwa bya CPPs kugirango byubake amakuru.Hashingiwe kuri aya makuru yamakuru, hakozwe ubushakashatsi bukurikira:

1, aside amine hamwe nuburyo bwa kabiri bigize CPP zitandukanye zikora na NonCPPs zasesenguwe na ANOVA.Byagaragaye ko imikoranire ya electrostatike na hydrophobi ya acide amine yagize uruhare runini mubikorwa bya transembrane ya CPPs, kandi imiterere ihindagurika hamwe no gutondeka bidasanzwe nabyo byagize ingaruka kubikorwa bya transembrane ya CPPs.

2. Imiterere yumubiri nubumara nuburebure bwa CPP nibikorwa bitandukanye byerekanwe kumurongo wibice bibiri.Byagaragaye ko CPP na NonCPPs zifite ibikorwa bitandukanye zishobora guhurizwa hamwe mubintu bimwe bidasanzwe, kandi HCPPs, MCPPs, LCPPs na NonCPPs bigabanyijemo amatsinda atatu, byerekana itandukaniro ryabo;

3. Muri iyi nyandiko, hashyizweho igitekerezo cya santride yumubiri na chimique ya biologiya ikurikirana, kandi ibisigisigi bigize urwo rutonde bifatwa nkibice bito, kandi uko byakurikiranye nkuburyo bwa sisitemu yubushakashatsi.Ubu buryo bwakoreshejwe mu isesengura rya CPP mu kwerekana CPP n'ibikorwa bitandukanye ku ndege ya 3D hakoreshejwe uburyo bwa PCA, kandi byagaragaye ko CPP nyinshi zishyize hamwe hamwe na LCPPs zimwe zishyize hamwe hamwe na NonCPPs.

Ubu bushakashatsi bufite ingaruka ku gishushanyo mbonera cya CPP no gusobanukirwa itandukaniro rikurikiranye rya CPP hamwe nibikorwa bitandukanye.Byongeye kandi, uburyo bwo gusesengura santride yumubiri nubumashini ya santride yibinyabuzima byatangijwe muriyi mpapuro birashobora no gukoreshwa mu gusesengura ibindi bibazo by’ibinyabuzima.Mugihe kimwe, zirashobora gukoreshwa nkibipimo byinjiza kubibazo bimwe na bimwe byibinyabuzima kandi bigira uruhare mukumenyekanisha.