Agoniste ya Glucagon imeze nka peptide 1 (GLP-1R) agoniste yasanze igabanya ikoreshwa ryinzoga mu nzoka ndetse n’abantu bafite ibiro byinshi bafite ikibazo cyo kunywa inzoga (AUD).Nyamara, ibipimo bike bya semaglutide (semaglutide), inzitizi ikomeye ya GLP-1, byagaragaye ko bigabanya ikoreshwa ryinzoga mu nzoka ndetse n’abantu bafite ibiro byinshi bafite AUD.Birashoboka ko agoniste ufite imbaraga nyinshi kandi akunda GLP-1R) yongerera ibisubizo biterwa n'inzoga mu nzoka, ndetse nuburyo bukoreshwa na neurologiya, ntibizwi.
Somallutide, imiti ikoreshwa muri iki gihe mu kuvura diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije, irashobora kuba uburyo bwiza bwo kunywa inzoga.mu bushakashatsi bwasohotse mu kinyamakuru mpuzamahanga eBioMedicine cyiswe “Semaglutide Igabanya Kunywa Inzoga no Kunywa nk'Imbeba Z'Abagabo n'Abagore,” Abahanga bo muri kaminuza ya Gothenburg ndetse no mu bindi bigo basanze somallutide ishobora kugabanya inzoga nyinshi ndetse no kunywa inzoga mu mbeba na barenze kimwe cya kabiri.
Ibisabwa kuri somallutide, bigurishwa ku mazina nka Ozempic (semaglutide), byariyongereye kuva imiti yemerewe kuvura umubyibuho ukabije, iherutse kugorana kuyibona;Habayeho kandi inkuru zidasanzwe z'abantu bafite umubyibuho ukabije cyangwa diyabete bavuga ko kwifuza inzoga byagabanutse nyuma yo gutangira gufata ibiyobyabwenge.Muri iki gihe, abantu bafite inzoga nyinshi bavurwa hakoreshejwe uburyo bwa psychosocial nibiyobyabwenge.Kuri ubu hari imiti ine yemewe.Kubera ko kunywa inzoga ari indwara ifite impamvu nyinshi kandi bigira ingaruka zitandukanye kuriyi miti, guteza imbere uburyo bwinshi bwo kuvura ni ngombwa cyane.
Somallutide ni ikiyobyabwenge kimaze igihe abarwayi bakeneye gufata rimwe mu cyumweru, kandi niwo muti wambere ukora kuri reseptor ya GLP-1 ishobora gufatwa nkibinini.Muri ubwo bushakashatsi, abashakashatsi bavuraga imbeba zishingiye ku nzoga na somalutide, ibyo bikaba byaragabanije cyane kunywa inzoga z’imbeba ndetse bikanagabanya kunywa inzoga zijyanye no gusubira inyuma, ikibazo gikomeye ku bantu bafite inzoga nyinshi kubera ko abantu basubira inyuma nyuma y’igihe cyo kwifata no kunywa inzoga nyinshi. kuruta uko babikoze mbere yo kwifata.Abashakashatsi bavuze ko imbeba zavuwe zashoboye kugabanya kunywa inzoga igice cya kabiri ugereranije n’imbeba zitavuwe.Icyagaragaye gishimishije muri ubwo bushakashatsi ni uko somallutide yagabanije kunywa inzoga zingana ku mbeba z’abagabo n’abagore.
Ubushakashatsi bwerekanye kandi ingaruka nziza zitangaje, nubwo ubushakashatsi bwubuvuzi bwa somallutide buracyari kure cyane mbere yuko bukoreshwa mu kuvura ibiyobyabwenge;Kujya imbere, ibiyobyabwenge bishobora kugirira akamaro cyane abantu bafite ibiro byinshi ndetse n’ibiyobyabwenge, kandi abashakashatsi bavuga ko ibisubizo bishobora kugeza ku bantu, kubera ko ubundi bushakashatsi bwakozwe ku biyobyabwenge biterwa n’inzoga ukoresheje urugero rw’ubushakashatsi buvuga ko abantu bashobora kugira ingaruka zo kuvura cyangwa ingaruka. nk'imbeba.Porofeseri Elisabet Jerlhag avuga ko, byanze bikunze, hari itandukaniro riri hagati y’ubushakashatsi bwakozwe mu nyamaswa n’abantu, kandi abashakashatsi bagomba guhora bazirikana ibyo bitandukanye;Muri uru rubanza ariko, ubushakashatsi bwibanze ku bantu bwerekanye ko verisiyo ishaje y’imiti ya diyabete ikora kuri GLP-1 yasanze igabanya kunywa inzoga ku bantu bafite ibiro byinshi bafite inzoga.
Ubu bushakashatsi bwanasuzumye impamvu ibiyobyabwenge somallutide bigabanya kunywa inzoga ku giti cye, byerekana ko kugabanya ibihembo by’ubwonko biterwa n’inzoga ndetse n’ibihano bishobora kuba intandaro;Muri urwo rupapuro, abashakashatsi basanze bigira ingaruka kuri gahunda yo guhemba no guhana ubwonko bwimbeba.By'umwihariko, bigira ingaruka kuri nucleus accumbens agace, kamwe muri sisitemu ya limbic.Abashakashatsi bemeza ko inzoga zikora gahunda yo guhemba no guhana ubwonko, bigatuma habaho irekurwa rya dopamine, ishobora kugaragara mu bantu no ku nyamaswa, kandi iki gikorwa kikaba cyarahagaritswe nyuma y’imbeba zimaze kuvurwa, bikaba byaviramo ibihembo bike biterwa n'inzoga kandi ibihano mu mubiri, abashakashatsi bemeza.
Mu gusoza, ibyavuye muri ubu bushakashatsi byerekana ko somallutide ishobora kugabanya imyitwarire yo kunywa inzoga, zishobora gukemurwa no kugabanya uburyo bwo guhembwa / guhanwa biterwa ninzoga hamwe nuburyo bwa nucleus accumbens.Ati: "Nkuko somallutide nayo yagabanije ibiro byumubiri mubitsina byombi byimbeba zinywa inzoga, ubushakashatsi bwamavuriro buzasuzuma akamaro ka somallutide mukugabanya gufata inzoga nuburemere bwumubiri kubarwayi bafite ibiro byinshi bafite ikibazo cyo kunywa inzoga."
Igihe cyo kohereza: Ugushyingo-07-2023