PYY peptide irwanya antifungal kandi ikomeza ubuzima bwa mikorobe yo munda

Igihe itsinda ryamenyaga ubu buryo bwa C. albicans ukoresheje PYY, amakuru yerekanaga ko PYY yahagaritse neza imikurire ya bagiteri, yica ubwoko bwinshi bwibihumyo bwa C. albicans kandi bugumana imisemburo ya symbiotic ya C. albicans.

Itsinda rya Eugene Chang muri kaminuza ya Chicago ryasohoye impapuro mu kinyamakuru Science cyitwa: Peptide YY: Peptide selile Panic selile anticicrobial peptide ikomeza Candida amara.

YY peptide (PYY) Ni imisemburo yo munda igaragazwa kandi ikarekurwa na selile enteroendocrine (ECC) kugirango igabanye ubushake bwo kurya ihagije.Ubushakashatsi buherutse gukorwa bwerekanye ko amara adasanzwe PanethCell agaragaza kandi uburyo bwa PYY, bushobora gukora nka peptide yica mikorobe (AMP), ikaba kandi igira uruhare runini mu gutuma mikorobe yo mu mara igira ubuzima bwiza kandi ikabuza Candida albicans kuba indwara itera indwara. uburyo.

Ntabwo bizwi cyane kubijyanye no kugenzura izo bagiteri na mikorobe yacu.Gusa tuzi ko bagiteri ziri hanze, ariko ntituzi icyabatera ubuzima bwiza.Ubushakashatsi buherutse gukorwa bwerekanye ko YY peptide ari ingenzi mu gukomeza indwara ya bagiteri yo mu nda.

Ku ikubitiro, itsinda ntabwo ryari ryiteguye kwiga bagiteri muri mikorobe yo mu nda.Igihe Joseph Pierre, umwanditsi wa mbere w’uru rupapuro, yiga ingirabuzimafatizo zo mu nda za PYY zitanga imbeba, Dr. Joseph Pierre yabonye ko PYY ifite na Panethcells, zikaba ari uburyo bukomeye bwo kwirinda indwara z’inda z’inyamabere kandi bikarinda kugwira kwa bagiteri zangiza. muguhinduranya ibintu byinshi bya bacterosuppressive.Ibi ntibisa nkibyumvikana kuko PYY yabanje gutekereza ko ari imisemburo yo kurya gusa.Iyo kipe imaze kumenya bagiteri zitandukanye, wasangaga PYY ari mbi kubica.

PYY peptide irwanya antifungal kandi ikomeza ubuzima bwa mikorobe yo munda

Ariko, igihe bashakishaga ubundi bwoko bwa peptide isa nuburyo, basanze peptide imeze nka PYY -Magainin2, peptide ya mikorobe irwanya uruhu rwa Xenopus irinda indwara ziterwa na bagiteri na fungal.Kubwibyo, itsinda ryiyemeje kugerageza imiti igabanya ubukana bwa PYY.Mubyukuri, PYY ntabwo ari imiti igabanya ubukana gusa ahubwo ni na antifungal yihariye.

PYY idahwitse, idahinduwe ifite aside amine 36 (PYY1-36) kandi ni peptide ikomeye ya antifungal mugihe selile Paneth ihinduranya munda.Ariko iyo selile endocrine itanga PYY, yamburwa acide ebyiri za amine (PYY3-36) hanyuma igahinduka imisemburo yo munda ishobora kunyura mumaraso kugirango habeho kumva wuzuye ubwira ubwonko ko udashonje.

Candida albicans (C.albicans), izwi kandi nka Candida albicans, ni bagiteri ikura mu kanwa, uruhu no mu mara.Nibisanzwe mumubiri muburyo bwibanze bwimisemburo, ariko mugihe giciriritse ihinduka muburyo bwitwa imiterere ya fungal, ituma ikura cyane, biganisha kumitsi, kwandura umunwa numuhogo, kwandura, cyangwa gukomera cyane kwandura sisitemu.

Igihe itsinda ryamenyaga ubu buryo bwa C. albicans ukoresheje PYY, amakuru yerekanaga ko PYY yahagaritse neza imikurire ya bagiteri, yica ubwoko bwinshi bwibihumyo bwa C. albicans kandi bugumana imisemburo ya symbiotic ya C. albicans.