Palmitoyl pentapeptide-4 irashobora kunoza uruhu rwo mumaso

Palmitoyl pentapeptide-4 isanzwe ikoreshwa nka gel fatizo kubirwanya uruhu rwangiza ibicuruzwa byita kuruhu

Palmitoyl pentapeptide-4 (pre-2006 palmitoyl pentapeptide-3) ikunze gukoreshwa nka gel fatizo kubirwanya imiti yangiza uruhu.Nibikorwa byuruhu rwo muri Espagne byita ku bikoresho bikora mu 2000 nkinganda zabo bwite zo kwita kubintu nkibikoresho bikora, palmitoyl pentapeptide-4 ni peptide ikurikirana cyane kandi ikoreshwa cyane na polypeptide, ibicuruzwa byamamaye mu gihugu ndetse n’amahanga bikoreshwa cyane nka ibyingenzi byingenzi muburyo bwo kurwanya uruhu rwokwitaho uruhu, mubicuruzwa byinshi birwanya uruhu byangiza uruhu bikunze kugaragara mubishusho byacyo.Mu kongera kolagene binyuze muri dermis, irashobora guhindura uburyo bwo gusaza mukubaka uruhu ruva imbere.Ingaruka za kolagen, fibre elastike na aside hyaluronike yiyongera, kongera ububobere bwuruhu no kugumana ubuhehere, kongera umubyimba wuruhu no kugabanya imirongo myiza.

Palmitoyl pentapeptide-4 (Pal-lys-thr-Lys-ser = Pal-KTTKS) irimo aside amine eshanu zifitanye isano n'iminyururu ya karuboni 16 ya karubone kugirango yongere ubushobozi bwa molekile binyuze mumiterere ya lipide y'uruhu.Iyi ni margarine.Palmitoyl pentapeptide-4 ni peptide yintumwa igenga imikorere ya selile ikorana niyakira ryihariye.Bakoze genes zigira uruhare mukuzamura matrise idasanzwe no gukwirakwiza selile.Palmitoyl pentapeptide-4 igira ingaruka zo kurwanya inkari no kwangiza uruhu mugukora synthesis nshya ya macromolecules muri matrice idasanzwe.

Uburyo bwibikorwa

Mu bushakashatsi bwa vitro bwerekanye ko 212% byiyongera mu bwoko bwa I collagen synthesis, ubwiyongere bwa 100% kugeza 327% mubwoko bwa IV bwa kolagen, hamwe na 267% byiyongera kuri synthesis ya hyaluronic.Kolagen I iboneka muburyo butandukanye bwa 19 bwa ​​kolagen mumubiri.Kubwibyo, kongera umusaruro wose wa kolagen I bifite ingaruka zikomeye mukubaka uruhu.Amezi atandatu mu bushakashatsi bwa vivo bwagaragaje ko impuzandengo yagabanutseho 17 ku ijana mu burebure bw’imirongo myiza, 68 ku ijana mu buso bw’imirongo yimbitse, 51 ku ijana mu buso bw’imirongo yoroheje, na 16 ku ijana mu bubi bwa uruhu.