Incamake hamwe nikoreshwa rya cerulein

Incamake

Caerulein, izwi kandi nka cerulein, ni uruhu rwuruhu rwibikeri byo muri Ositaraliya HYlacaerulea bigizwe na acide 10 amine.Ni molekile ya decapeptide itangwa na trifluoroacetate ikora nka analoge ya cholecystokinin kuri selile pancreatic vesicular selile kandi ishobora gutuma habaho gusohora imisemburo myinshi yimisemburo hamwe n umutobe wa pancreatic, bikaviramo pancreatite ikabije.Cerutine irashobora gukoreshwa mukwiga poroteyine Nf-κb up-reguline nka molekile-1 (ICAM-1) intercellular adhesion molekile-1 (ICAM-1) ibintu bifitanye isano no gutwika nka NADPH oxydease na Janus kinase byahujwe no gukwirakwiza ibimenyetso.Yakoreshejwe neza mugushiraho icyitegererezo cya pancreatite ikaze yimbeba, imbeba, imbwa, na siriya yo muri Siriya (AP).Amazi ava mumitsi atangwa neza mugutera inshinge, dermal, cyangwa intraperitoneal.Ikoreshwa cyane mubushakashatsi bwamavuriro ya pancreatite ikaze, kandi mubushakashatsi bwa vitro bukoreshwa muburyo bwimikorere.Mubyongeyeho, ikoreshwa mugusuzuma imikorere ya gallbladder.

Incamake hamwe nikoreshwa rya cerulein

Amakuru arambuye

Kugaragara: ifu yera

Numero ya CAS: 17650-98-5

Gutuo Oya: GT-F055

Urukurikirane: pGlu-Gln-Asp-Tyr (SO3H) -Thr-Gly-Trp-Met-Asp-Phe-NH2

Inzira ya molekulari: C58H73N13O21S2

Uburemere bwa molekuline: 1352.4

Gukemura: Bishonga muri 50mM hydroxide ya ammonium kuri concentration ya 1.0mg / ml

Gusaba

1. Irakoreshwa cyane muburyo bwo kwerekana imiterere ya pancreatitis ikaze cyane.

2. Gushyira mubikorwa bya selile muri vitro.

3. Byakoreshejwe mugupima imikorere ya gallbladder.

Gutegura icyitegererezo cyo kwiga pancreatite ikaze yo kwiga ibinyabuzima bya selile cerulein (AP), imiterere ya patrophysiologique no kwerekana indwara kama muri pancreatite ikaze.Usibye gukora iperereza ku mpinduka z’ibihaha z’indwara ya AP, irashobora kandi kwerekana neza imikoranire ya visceral endocrine nkurwego rwa metaboline na CCK.Irashobora kandi gukoreshwa mugusuzuma gusubiza mu buzima busanzwe no gukira kw'imitsi yakomeretse nyuma yo kurangiza ibintu bishobora guteza akaga.

5Ibikurikira, LPS ihagarika igisubizo gisanzwe cyabunzi batera umuriro, bityo igatera pancreatite yaho nkikintu gikomeye cyo gutwika ibintu.

6. Cerulein irashobora gukoreshwa kugirango wirinde ububabare bwa gallbladder, colic impyiko, nububabare bwa claudication rimwe na rimwe.Mubisanzwe bifatwa nka endogenous kephalin antagonist.