Uburyo bwa protease ibikorwa bya sisitemu

Uburyo bwibikorwa

Enzymes ni poroteyine zitera imiti.Enzyme ikorana na substrate kugirango ihindure ibicuruzwa byanyuma.Inhibitor zirahuza kugirango zibuze substrate kwinjira kurubuga rukora rwa enzyme kandi / cyangwa kubuza enzyme guhagarika reaction.Hariho ubwoko bwinshi bwa inhibitor zirimo: zidasanzwe, zidasubirwaho, zisubira inyuma - irushanwa kandi ridahiganwa.Inhibitori ihindagurika ihuza imisemburo hamwe n’imikoranire idahwitse (urugero, imikoranire ya hydrophobique, hydrogen na ionic bond).Ingamba zidafite akamaro zirimo amaherezo yo gutandukanya igice cya poroteyine ya enzyme bityo ukirinda ingaruka zose zumubiri cyangwa imiti.Inhibitor zihariye zikora kuri enzyme imwe.Uburozi bwinshi bukora ukurikije imisemburo yihariye yo kugenzura.Kurwanya inhibitori nibintu byose bisa neza nuburyo bwa chimique na geometrike ya geometrike ya reaction substrate.Inhibitor irashobora gukorana na enzyme kurubuga rukora, ariko nta reaction ibaho.Inhibitor zidahiganwa ni ibintu bikorana na enzymes ariko ahanini ntibikorana kurubuga rukora.Intego nyamukuru ya inhibitor idahiganwa ni uguhindura imiterere ya enzyme, bityo bikagira ingaruka kurubuga rukora, kugirango substrate itagishoboye gukorana na enzyme kugirango ikore.Inhibitor zidahiganwa ahanini zirahindurwa.Inibitori idasubirwaho ikora imiyoboro ikomeye ya covalent hamwe na enzymes.Bimwe muribi bibuza gukora kurubuga cyangwa hafi yurubuga rukora.

Koresha

Enzymes ikoreshwa cyane mubucuruzi mu nganda, nko koza ibikoresho, ibiryo n'inganda zikora inzoga.Poroteyine zikoreshwa mu ifu yo gukaraba “mikorobe” kugirango yihutishe isenyuka rya poroteyine mu mwanda nk'amaraso n'amagi.Gukoresha ubucuruzi bwa enzymes bikubiyemo ko bishonga amazi, bigatuma bigorana kuyitunganya, kandi ko ibicuruzwa bimwe byanyuma bibuza ibikorwa bya enzyme (kugenzura ibitekerezo).

Molekile yibiyobyabwenge, molekile nyinshi yibiyobyabwenge ni inhibitori ya enzyme, kandi ibiyobyabwenge byangiza imiti akenshi birangwa numwihariko n'ingaruka zabyo.Umwihariko hamwe n'ingaruka byerekanaga ko ibiyobyabwenge byagize ingaruka nke kandi bifite uburozi buke.Enzyme inhibitor iboneka muri kamere kandi irateganijwe kandi ikorwa nkigice gito cya farumasi na biohimiki 6.

Uburozi karemano ahanini ni inzitizi ya enzyme yagiye ihinduka kugirango irinde ibiti cyangwa inyamaswa zitandukanye inyamaswa zangiza.Ubu burozi busanzwe burimo byinshi muburozi bwuburozi bwigeze kuvumburwa.