Ibintu bine biranga peptide ya mikorobe

Iyi peptide yica mikorobe yabanje gukomoka muri sisitemu yo kurinda udukoko, inyamaswa z’inyamabere, amphibian, nibindi, kandi zirimo ibyiciro bine:

1. cecropine yabanje kuboneka muri lymph immunite ya Cecropiamoth, iboneka cyane mu yandi dukoko, kandi peptide ya bactericidal nayo iboneka mu mara y'ingurube.Mubisanzwe barangwa na alkaline ikomeye N-terminal akurikirwa nigice kinini cya hydrophobique.

2. Xenopus antimicrobial peptide (magainin) ikomoka kumitsi nigifu cyibikeri.Imiterere ya peptide ya xenopus antimicrobial peptide nayo wasangaga ihindagurika, cyane cyane mubidukikije bya hydrophobique.Imiterere ya xenopus antipeptide murwego rwa lipide yakozwe na N-yanditseho icyiciro-NMR.Hashingiwe ku guhinduranya imiti ya acylamine resonance, helices ya antipeptide ya xenopus yari igereranijwe na bilayeri, kandi irashobora guhurira hamwe ikagira akazu ka 13mm gafite imiterere ya 30mm.

3. defensin Defence peptide ikomoka kuri polykaryotic neutrophil urukwavu polymacrophage hamwe na lobule yuzuye ya kirimbuzi hamwe ningirangingo zo munda zinyamaswa.Itsinda rya peptide ya mikorobe isa na peptide yo mu bwoko bw’inyamabere yakuwe mu dukoko, bita “peptide defence peptide”.Bitandukanye na peptide yirinda inyamaswa z’inyamabere, peptide yo kwirinda udukoko ikora gusa kurwanya bagiteri nziza.Ndetse peptide irinda udukoko irimo ibisigazwa bitandatu bya Cys, ariko uburyo bwo guhuza disulfide buratandukanye.Uburyo bwo guhuza ikiraro cya disulfide ihuza uburyo bwa peptide ya antibacterial yakuwe muri Drosophila melanogast yari imeze nka peptide yo kurinda ibimera.Mubihe bya kristu, peptide yo kwirwanaho itangwa nkibipimo.

4.Tachyplesin ikomoka ku gikona cy'amafarashi, cyitwa horsehoecrab.Ubushakashatsi bwiboneza bwerekana ko bufata ibipimo bya B-bigereranya (imyanya 3-8, imyanya 11-16), ahoβ-urukiramende ruhujwe (imyanya 8-11), kandi imiyoboro ibiri ya disulfide ikorwa hagati yimyanya 7 na 12, no hagati yimyanya 3 na 16.Muri iyi miterere, aside hydrophobique amino iherereye kuruhande rumwe rwindege, kandi ibisigazwa bitandatu bya cationic bigaragara kumurizo wa molekile, bityo imiterere nayo ni biofilique.

Bikurikiraho ko peptide hafi ya zose zirwanya mikorobe zifite imiterere, nubwo zitandukanye muburebure n'uburebure;Ku mpera yo hejuru, haba muburyo bwa alpha-helical cyangwaβ-gukuba, imiterere ya bitropique nicyo kintu gisanzwe.