Itandukaniro mubidukikije aho umunyu wa TFA, acetate, na hydrochloride bikoreshwa muri synthesis ya peptide

Mugihe cya peptide synthesis, hagomba kongerwamo umunyu.Ariko hariho ubwoko bwinshi bwumunyu, kandi ubwoko butandukanye bwumunyu bukora peptide zitandukanye, kandi ingaruka ntabwo arimwe.Uyu munsi rero duhitamo cyane ubwoko bukwiye bwumunyu wa peptide muri synthesis ya peptide.

1. Trifluoroacetate (TFA): Uyu ni umunyu ukunze gukoreshwa mubicuruzwa bya peptide, ariko ugomba kwirinda mu bushakashatsi bumwe na bumwe bitewe na biotoxicity ya trifluoroacetate.Kurugero, ubushakashatsi bwakagari.

2. Acetate (AC): Biotoxicity ya acide acetike iri munsi ya acide trifluoroacetic, bityo peptide nyinshi yimiti na cosmetike peptide ikoresha acetate, ariko ibicuruzwa bimwe na bimwe bifite acetate idahindagurika, bityo rero hagomba kwitabwaho ihame ryurwego.Acetate yatoranijwe kubushakashatsi bwinshi.

3. Acide Hydrochloric (HCL): Uyu munyu ntiwatoranijwe gake, kandi gusa urutonde rukoresha aside hydrochloric kubintu byihariye.

4. Umunyu wa Amonium (NH4 +): Uyu munyu uzagira ingaruka zikomeye kumashanyarazi no guhagarara kwibicuruzwa, bigomba gutoranywa bikurikiranye.

5. Umunyu wa Sodium (NA +): muri rusange bigira ingaruka kumyitwarire no gukomera kwibicuruzwa.

6. Pamoicacid: Uyu munyu ukunze gukoreshwa mumiti ya peptide kugirango ikore ibintu-birekura.

7. CitricAcid: Uyu munyu ufite uburozi buke bwa physiologique, ariko kubitegura biragoye cyane, kuburyo inzira yumusaruro igomba gutezwa imbere bikurikiranye kandi bitandukanye.

8. Salicylicacid: Salicylate irashobora kugira ingaruka ku bicuruzwa bya peptide, bityo ntibikoreshwa gake.

Ibyavuzwe haruguru ni ubwoko bwinshi bwumunyu wa peptide, kandi tugomba no guhitamo dukurikije ibiranga imyunyu itandukanye mugukoresha nyirizina.