Ese trifluoroacetyl tripeptide-2 ishobora gutinda gusaza?

Ibyerekeye:

Peptide ni urunigi rwa aside amine ihujwe na peptide.Peptide igira uruhare runini mugutunganya poroteyine, angiogenezi, gukwirakwiza selile, melanogenezi, kwimuka kwakagari, no gutwika.Bioactive peptide yakoreshejwe cyane munganda zo kwisiga mumyaka mirongo ishize.Peptide isaba uburemere buke bwa molekile (> 500 Da), kugirango igabanye ikwirakwizwa rya peptide hagati yicyorezo cya epidermal, ituze ryinshi kandi ikemuka.Mu myaka yashize, umuryango wubumenyi wateje imbere agace gato kandi gahamye ka peptide ya peptide ikora umusaruro wa kolagen kandi igabanya iminkanyari zo mumaso hamwe na pigmentation.Trifluoroacetyl tripeptide-2 (ikurikiranye: TFA-Val-Gerageza-Val-OH) synthesis ya tripeptide, yakozwe nka matrix metalloproteinase na inhibitor ya elastase.Mu bushakashatsi bwa vitro ku bijyanye no kurinda ECM na trifluoro-acetyl tripeptide 2 (TT2), synthesis ya proteoglycan mu mikorere ya selile-matrix, hamwe n'ingaruka kuri synthesis ya progerin muri fibroblast isanzwe y'abantu bakuze vuba aha byagaragaye ko ari intandaro ya selile. senescence.Ibisubizo byerekana ko trifluoroacetyl tripeptide 2 ifite intera nini yo kurwanya gusaza.Ibi bigabanya synthesis ya progerin, byongera umusaruro wa proteoglycan, kandi bigabanya kolagen, bityo bikagabanya iminkanyari no kunoza ingirabuzimafatizo.Byongeye kandi, ingaruka zacyo zo kurwanya inkari, kurwanya kumanika no kugabanya uruhu zasuzumwe muri ebyiri mu bushakashatsi bwakozwe na vitro.Trifluoroacetyl tripeptide 2 yerekanwe ko igira ingaruka zigenda zitera inkeke, gukomera, gukomera, no kugabanuka.

Ese trifluoroacetyl tripeptide-2 ishobora gutinda gusaza?

Ubushakashatsi bwerekanye ko senescence ya selile ifitanye isano ya hafi na Progerin.Hamwe no gusaza, preseniline yegeranya byinshi mu mubiri, biganisha ku nenge za kirimbuzi no kwangirika kwa ADN, biganisha ku gusaza kwuruhu.Trifluoroacetyl tripeptide-2 ni tripeptide ikora ya Elafin, ikomoka kuri elastase inhibitor.Igabanya synthesis ya Progerin kandi itezimbere uruhu, kugabanuka no kubyimba.

Urwego

1. Kubuza synthesis ya Progerin kugirango utinde senescence ya selile.

2. Guteza imbere umusaruro wa syndecan no kongera ubuzima bwakagari.

3. Kubuza ibikorwa bya matrix metalloproteinase MMP1, MMP3 na MMP9, kugabanya isenyuka rya poroteyine zidasanzwe zidasanzwe kandi ukomeze ubusugire bwazo.

4. Kubuza ibikorwa bya elastase, kugabanya kwangirika kwa elastine, no gutuma uruhu rukomera kandi rworoshye.

Gusaba

Irakwiriye muburyo bwose bwo kurwanya inkari no kurwanya gusaza, gusana umuriro, kurwanya ifoto, kwita kumubiri nyuma yizuba na nyuma yizuba, nibindi byongewe mubyiciro byanyuma byo kwisiga