Ese peptide ya antibicrobial Omiganan nayo ishobora kugera kuri antibacterial

Icyongereza: Omiganan

Numero ya CAS: 204248-78-2

Inzira ya molekulari: C₉₀H₁₂₇N₂₇O₁₂

Uburemere bwa molekuline: 1779.15

Urukurikirane: ILRWPWWPWRRK-NH2

Kugaragara: ifu yera cyangwa yera yera

Uburyo Omiganan akora:

Ni peptide ntoya cyane rero biragoye kumenya no kuranga proteolysis;Irahujwe kuri C terminus kugirango irusheho kurwanya proteolysis no gukuraho amafaranga mabi yitsinda rya carboxyl.Ni amphiphilic kandi irashobora gukorana cyane na selile.Utugingo ngengabuzima twitezwe kuba imwe mubyo bagamije.Ni polycation ishyigikira imikoranire yabo na bagiteri zatewe nabi na bagiteri zomeric zo hanze ya lipopolysaccharide (LPS) hamwe na membrane yinyamabere aho kuba peptidoglycan.Muri bagiteri, ubushobozi bwa membrane nabwo ni bubi kuruta mu ngirangingo z’inyamabere, zishobora kongera antibiyotike guhuza no guhinduranya.Ikintu cya nyuma ni inenge ivura ko anti-flammatory cytidine nayo ifite ibikorwa kuri erythrocytes, mugihe Omiganan isa nkaho idafite amaraso make.Nkuko byavuzwe haruguru, ibisigisigi byashizwemo bya omiga-nan biherereye hafi ya buri terminal, kure yakarere ka hydrophobique rwagati ya peptide, kandi amafaranga meza ya peptide yiyongera kuva kuri 4+ kugeza kuri 5+, ibyo bikaba bishobora gusobanurwa no kugabanuka kwa hemolysis. , kubera ko izi mpinduka zitari nziza kubintu bisa na peptide bifitanye isano na zwitt-rionic mammalian membrane.Ibi bishimangirwa nibisubizo bya Staubitz nabandi, aho igice cyo hagati ya cetin yabitswe ya antinflammatory cetin muri omiganan ifitanye isano nibikorwa, mugihe igice cyanyuma gisa nkicyahinduye umwihariko wintego.

Omiganan ikoreshwa kuri:

Omiganan nigitabo gishya cyitwa syntique cationic antimicrobial peptide kuri ubu kirimo gutegurwa hagamijwe gukumira indwara ziterwa na catheteri no kuvura acne na rosacea.Muri ubu bushakashatsi, twasuzumye imikorere yo gukoresha gel ya omiganan muburyo bubiri bwatewe uruhu (muruhu rwa vivo porcine no muruhu rwa vivo guinea).omiganan0 yapimwe muri ex vivo porcine uruhu rwo gukoroniza uruhu 1 kugeza 2% bya agent ya gel yerekanaga ingaruka zikomeye ziterwa na Gram-positif na Gram-negative bagiteri n'imisemburo, hamwe n'ingaruka nini zagaragaye hagati ya 1 na 2%.Nta tandukaniro rikomeye ryagaragaye mu bikorwa hagati ya methicilline irwanya kandi ishobora kwandura Staphylococcus aureus, kandi ibikorwa by’ibiyobyabwenge ntabwo byatewe nubunini bwikintu cyatewe.Gel ya Omiganan1% yari ifite ibikorwa byihuse bya mikorobe, hamwe no kugabanuka kwa 2.7log (10) kugabanura ibice bigize koloni ya epidermolis ya Staphylococcus kuri site 1 h hamwe no kugabanuka kwa 5.2log (10) kuri flagella / site saa 24 h nyuma yo kubisaba.Igikorwa gikomeye cya antibacterial na antifungal ya Omiganan1% gel cyemejwe nubundi bushakashatsi bwakozwe muburyo bwa koloni ya dolphine.Muri make, geles ya Omiganem yerekanwe ko ifite ingaruka zihuse za bagiteri na bagiteri ziterwa ningaruka zifatika ziterwa nibice byinshi byanduye.Ibisubizo biragaragaza kandi ubushobozi bwibiyobyabwenge nkumuti wingenzi wa mikorobe.