N-acetylsemax / GT Peptide / Utanga Peptide

Ibisobanuro

N-ACETYL SEMAX nuburyo bwa syntetique ya peptide ikaba igereranya imisemburo ACTH.Nyamara, ACTH nibisa nayo bifite ingaruka zidasanzwe, nko kuzamura ubushobozi bwo kwiga no kwibuka, no gukomeza imitsi.Uburyo bwibikorwa byuru ruganda ntabwo byunvikana neza kandi birashobora guterwa ningaruka kuri reseptor ya melanocortine iri muri sisitemu yimitsi.Igikorwa cyingenzi cya semax nugukangura synthesis yibintu bikomoka mubwonko bikomoka kuri neurotrophique (BNDF).Iyi ni peptide ikorwa na neuron ikenerwa mumikorere ya retina (niyo mpamvu itandukaniro rinini kandi igaragara neza nyuma yo gukoresha ibintu bya nootropique), cholinergique, na neuron ya dopaminergique.Kubaho kwiki kintu bitera iterambere ryimitsi mishya kandi ikongerera igihe ingirabuzimafatizo zihari.Ifite uruhare runini mugushinga kwibuka igihe kirekire nibikorwa byose byubwonko bifitanye isano no gushiraho neuron nshya - ndetse no mukwiga ingendo nshya cyangwa kuzamura imbaraga

Ibisobanuro

Kugaragara: Ifu yera-yera-ifu

Isuku (HPLC):≥98.0%

Umwanda umwe:≤2.0%

Ibirimo Acetate (HPLC): 5.0%～12.0%

Ibirimo Amazi (Karl Fischer):≤10.0%

Peptide Ibirimo:≥80.0%

Gupakira no kohereza: Ubushyuhe buke, gupakira vacuum, neza kuri mg nkuko bisabwa.

Nigute ushobora gutumiza?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Tegeka kumurongo.Nyamuneka wuzuze urupapuro rwabigenewe.

3. Tanga izina rya peptide, CAS Oya cyangwa urutonde, ubuziranenge no guhindura niba bikenewe, ubwinshi, nibindi tuzatanga cote mumasaha 2.

4. Tegeka guhinduka ukoresheje amasezerano yo kugurisha yasinywe byemewe na NDA (amasezerano yo kutamenyekanisha) cyangwa amasezerano yibanga.

5. Tuzakomeza kuvugurura iterambere ryateganijwe mugihe.

6. Gutanga peptide na DHL, Fedex cyangwa abandi, na HPLC, MS, COA bizatangwa hamwe n'imizigo.

7. Politiki yo gusubizwa izakurikizwa niba hari itandukaniro ryubwiza cyangwa serivisi.

8. Serivisi nyuma yo kugurisha: Niba abakiriya bacu bafite ikibazo kijyanye na peptide mugihe cyibigeragezo, nyamuneka twandikire natwe tuzagusubiza mugihe gito.

Ibicuruzwa byose byikigo bikoreshwa gusa mubushakashatsi bwubumenyi, ni's bibujijwe gukoreshwa mu buryo butaziguye n'abantu bose ku mubiri w'umuntu.

Ibibazo：

Ese peptide irimo Cys yagabanutse mbere yo koherezwa?

Niba peptide itabonetse ko yahinduwe okiside, mubisanzwe ntabwo tugabanya Cys.Polypeptide yose iboneka mubicuruzwa bitarimo isuku kandi byitwa lyofilize mubihe bya pH2, byibuze byibuze bikabuza okiside ya Cys.Peptide irimo Cys isukurwa kuri pH2 keretse niba hari impamvu yihariye yo kweza kuri pH6.8.Niba kweza bikozwe kuri pH6.8, ibicuruzwa bisukuye bigomba guhita bivurwa na aside kugirango birinde okiside.Mu ntambwe yanyuma yo kugenzura ubuziranenge, kuri peptide irimo Cys, niba hari uburemere bwa molekile (2P + H) buboneka ku ikarita ya MS, byerekana ko hashyizweho dimer.Niba ntakibazo gihari kuri MS na HPLC, tuzahita dusohora lyofilize no kohereza ibicuruzwa nta yandi mananiza.Twabibutsa ko peptide irimo Cys igenda ihindagurika buhoro buhoro mugihe, kandi urugero rwa okiside rushingiye kuri peptide ikurikirana nuburyo bwo kubika.

Nigute ushobora kumenya niba peptide ifunguye?

Dukoresha Ellman reaction kugirango tumenye niba impeta yuzuye.Niba ikizamini cya Ellman ari cyiza (umuhondo), impeta yuzuye ntabwo yuzuye.Niba ibisubizo byikizamini ari bibi (ntabwo ari umuhondo), impeta yuzuye yarangiye.Ntabwo dutanga raporo yisesengura ryerekana cycleisation kubakiriya bacu.Mubisanzwe, hazaba ibisobanuro byibisubizo bya Ellman muri raporo ya QC.

Nkeneye peptide ya cyclicique, irimo tripitofani, izaba oxyde?

Okiside ya tryptophan ni ibintu bisanzwe muri okiside ya peptide, kandi peptide ikunze kuzunguruka mbere yo kwezwa.Niba okiside ya tryptophan ibaye, igihe cyo kugumana peptide kumurongo wa HPLC kizahinduka, kandi okiside irashobora gukurwaho no kwezwa.Byongeye kandi, peptide ya okiside irashobora kandi gutahurwa na MS.

Birakenewe gushyira icyuho hagati ya peptide n irangi?

Niba ugiye kwomeka kuri molekile nini (nk'irangi) kuri peptide, nibyiza gushyira umwanya hagati ya peptide na ligand kugirango ugabanye kwivanga kwakirwa na peptide ubwayo cyangwa mukuzinga kwa conjugate.Abandi ntibashaka intera.Kurugero, mugukingira poroteyine, birashoboka kumenya intera itandukanijwe yimiterere ya aside amine muguhuza irangi rya fluorescent kurubuga runaka.

Niba ushaka gukora biotin ihindura kuri N terminal, ukeneye gushyira icyuho hagati ya biotine na peptide ikurikirana?

Uburyo busanzwe bwo kuranga biotine bukoreshwa nisosiyete yacu ni uguhuza Ahx kumurongo wa peptide, ugakurikirwa na biotine.Ahx ni karuboni 6 ikora nka bariyeri hagati ya peptide na biotine.

Urashobora gutanga inama kubijyanye no gushushanya peptide ya fosifora?

Mugihe uburebure bwiyongera, guhuza imbaraga bigenda bigabanuka buhoro buhoro bivuye kuri fosifori ya amine acide ikomeza.Icyerekezo cya synthesis ni kuva kuri C terminal kugeza kuri N terminal.Birasabwa ko ibisigazwa nyuma ya fosifori ya amine acide itagomba kurenga 10, ni ukuvuga umubare wibisigisigi bya aside amine mbere yuko aside amine ya fosifora iva muri N kugeza kuri C itagomba kurenga 10.

Kuki n-terminal acetylation na C-terminal amidation?

Ihinduka ririnda peptide guteshwa agaciro no kwemerera peptide yo kwigana imiterere yumwimerere ya alpha amino na carboxyl matsinda muri proteine ​​yababyeyi.